If I understand your intended arrangement there should be little in the way of problems. The span is really the center to center distance and if that becomes excessive you should ad idlers mid span. 4" isn't a problem and frankly Ive seen as much as 8 inches between the leadscrew and the driver. This on a high precision lathe two. The important thing is to select high quality pulleys and belts that run smoothly together and make sure your alignmentt of the parts is accurate. The fact is a belt drive between a motor and a lead screw is common practice in automation and machine tools. It is the cheapest way to implement a mild ratio between the leadscrew and driver.
However with gear ratios come other issues, make sure you need a ratio over a 1:1 drive.