Charge pump is a PWM pulse train. You can use an external electronics to sense the pulses and that electronics can switch an output on if the pulses are OK and off if the pulses are missing.
You can use that circuit to switch things off in your control box if the pulses are missing because the connection is broken between the PC and the motion controller.
You can use an enable signal too instead of a charge pump. The UC controller will switch that off too if it looses the connection for example if the PC freeze.