I've been running mine set to 2 or 3, without any issues. I don't know what's considered "safe".
In Mach3, ports and pins, are the spindle delay settings.
I think the general consensus, and what sellers recommend, is 6,000 for water cooled, and 8,000 for air cooled. There are plenty of people that run them much slower. (And plenty of people that burn up their spindles almost immediately).