The real question is: Why would you home a mill without a tool changer? I'm not being flippant here, there really is no reason to do it.
You are going to set your G54 0,0,0 to the workpiece anyway. You might want to set a G53 ''parking position'' to move the table and head to a convenient location on job completion to facilitate measuring or part load/unload. On my mill the machine coordinates are always the same as the work coordinates, and move around with a new job, and the G53 varies with the job.
This does preclude using soft limits, so it's up to you to insure the machine is going to work within the acceptable work envelope.