If you only have X and Y, you can simply disable Z axis. I believe when you disable Z, all the other Z options are 'greyed' out.
If you don't have a Z axis, or do have one and don't want it to move, I would definately suggest you disable it. Just in case a Z move gets in the program.
As far as the plasma screen in Mach2, I've never used it. So the above is based on the milling sections of Mach2.