It may depend on what coolant you're running, at what concentration, and how long between cleanings you go. I use Blaser coolant at 8% and don't let the machine get very dirty. Windex cleans the outside with almost no effort, and the inside of the machine is pristine with no cleaning at all.
If you have the time, now might be a good time to take all the way covers off to unstick them as well as having a look at what's underneath. Make sure there's not too many chips getting in, make sure the ways are wet with way lube, make sure nothing is rusting real bad, etc.
All I do for maintenance is check all the lube points (SMTC, gear box if you have one, etc.) and make sure the way lube pump is operating properly. Check to see the air regulators are still set correctly. Check tram to see if the machine has settled any. I think that's about all you can do, but if I'm wrong someone will add their own list shortly.