For your reading enjoyment
https://www.carlislesyntec.com/downl...34&fileID=6830
https://www.creativemechanisms.com/b...ut-pvc-plastic
Google Search: is pvc toxic when heated
Based on the quick reading I just did, I would want really good ventilation in the area of cutting (inside the laser cabinet) that is exhausted outside of the building, preferably through an external filter system. Once the plastic has cooled it should be perfectly safe to handle, only the smoke is harmful.