it all depends on if its a program move or a manual move. If you have mirror image turned on and its being driven by program then it will go in the wrong direction. If it is a manual move i.e. JOG then maybe someone changes a parameter:
Parameter 0012 bit 0 MIRx Mirror image for each axis
0 : Mirror image is off.
1 : Mirror image is on.
Parameter 2022 Direction of motor rotation: JOG Direction
111 clockwise
-111 counter clockwise