Hi mmurrary70,
When the problem occurs before re-initializing you might determine the reason the IO isn't working. Did you try toggling the IO with the digital IO screen? Is the bit shown set on the screen but physically not? Did you check the pin voltage and supply voltages?
I can't think of a way Kanalog relay drivers would stop responding. Unless Kanalog communication has somehow stopped. Is the Kanalog charge pump Enable LED on? Or if a Program was continuously writing to the IO. Halt all Programs and then check if the IO works.
If you post the code we can look it over.
Regards