Thanks Cyclestart - I have a router, but I'd certainly need to load some of the milling bits into it right?.. I'll looking how to do that before I hurt myself haha.
So I have taken everyone's advice. Keen for some feedback. See the attached images
Key Changes:
1. Will update Z-axis to include the bearings on the fixed side, and rails on the spindle side. This will help keep the bearings more separate and gives me now a z-axis range of 160-170mm. I'm happy with that.
2. Updated X-axis rails from 1 ballscrew underneath, to two on either side of the base. I will put some 110x16mm or 110x12mm flat plate on top of the 80x120 Alum T-Slot to mount everything to. This allows me to move the ballscrew closer to the gantry side so there is better clearance. Later I will also add some kind of protective case over the entire side like what is done in the "ripper" build. This was the best spot which allowed me to the fit the motor without hanging over the edge. Happy for any other ideas!
See pictures for the rough concept.
Notes about the rest of design:
I wanted to keep the Gantry as it is. It seems simple enough to build without over complicating things. I will put some reinforcing bracks between the two 80x80 on the rear side later.
I decided to keep the connecting 40x80 t-slot which runs underneath. Most of these designs have something like this, and will hope it keeps everything more stable. I may change this to either 40x120 T-slot OR 20mm thick plate (also 120mm wide).
What do you think? And yes, took everyones feedback and will certainly finish the design before ordering parts. I have already ordered the NEMA34 motors, DMA860H Controllers and 48V power supplies (4pcs of each) so going to make that work. For ball screws etc I will get new ones to suit the design.
EDIT: I noticed some of my models didn't update correctly - ignore some of the basic errors (like bearing locations, plate not going all way to the end etc).