looks like the legs are a lot better and the design you have now looks like a lot more of what you see the majority doing. i'm not in the majority but the guy paying the bills for the build has the final say every thing looks well placed at a glance. the closer you can keep the center line of you spindle to the gantry cross beam the better. keeps things more rigid. as long as you are over top of the bearing trucks when the spindle is down i would think you are ok. spacing is something that is important, to little is no good and to much is no good either. but what you have looks ok. this type of machine has deflection to some degree so it;s hard to get rid of it all. HSM advisor will tell you how much force you have while cutting i would expect things to fall between 25 to 50 pounds at the spindle. if you planning on doing a lot of 3D milling for mold making those kinds of tool paths don't usually have heavy loads to begin with but you can control the roughing quite a bit with modern tool paths to keep the loads down you just trade off time for material removal rates.