Hi F8- There are two main schools of thought:
1) Overhangs are fine you need to make the overhang stiff for plunging loads. There is a name for the proportion of the overhang and it slips my mind at the moment. But it's for heavy beds that have to take the weight of the bed into account so it evens out.
2) Put the bearings at the edges. Then the middle has to be stiff enough for the plunging loads of the cutter.
Putting the bearings at the ends uses the most space, putting the bearings inboard uses less axis space. So pick your geometry to suit. A good method if you are using cheap bearings is to use 3 bearings per side (end, middle, end) this solves many flex issues and improves the movement of the bed. The cost of a bearing is usually small in proportion to the rest of the $$$.
Cheers Peter