It took me a while to determine what would be best for my long term goals to get the machine I wanted for what I am and will be making. I opted for a 5x5' Pro Avid kit, Centroid Acorn with Wireless MPG, Clear Path Servos, and CNC Depot S30C spindle with ATC. More work and more $$ out of the gate, but the ATC and added power/accuracy of the servos will reduce the overall time compared to my current process. The larger bed will allow for multiple fixtures for my parts, and allow me to clamp the outside of 4' wide sheets.
I have been using arduino based CNCs for a few years and have observed the issues in the forums of the different brands of controllers and software interfaces. For the level of work I want to achieve the Centroid Acorn was a better choice for me over Mach 4 and ESS. ]
Take the time and determine what you like, dislike, and wish you had from your current system, then list them out and see what fits your needs.