The lower left point in the XY datum is some point on the actual part. could be the lower left corner or a hole in the part. On the drawing it is the lower left of the material. Just like center point XY datum is the 0,0 of the drawing. So if your material is 12X12 then it’s the lower left of that 12X12 square.
Use offset to offset that XY datum to your hole at .5 and 2.25. So when using that offset I think you zero the machine at the corner and it cuts like it was zeroed at the hole. I’d run a test cut above the part just to verify.
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