What would you be getting for $80K? Probably something with a multiple spindle boring head? I'd say it's unlikely you can duplicate that type of machine as a DIY project.
Generally, the more things you want the machine to do, the fewer things it will be really good at. I would say that plasma isn't even an option.
How many sheets of melamine do you cut each day? I would say that a machine for cutting melamine cabinet part won't be good at milling horizontal edges in hardwood. Mainly due to the workholding requirements, and the time it takes to switch from a nested based vacuum table to something with elevated vacuum clamping. You'd also need a 90° aggregate head, which can cost $10K for that alone.
You'll want to use vacuum for holding down sheet goods, and a 5x12 table requires a lot of vacuum. We have a 5x12 at work that uses two 10HP Becker pumps, and it's barely adequate when cutting smaller parts. And that's nearly $20K in vacuum pumps. The only time we really use all 12 feet is when cutting Corian sheets.