epoxy with an aggregate is a material that doesn't retain bonding to steel well over time but the aggregate does help in this case, something that has a smooth finish from machining, if using round-stock a helix pattern is the way to go as the insert will eventually release over time.
The frames I've been casting lately require no machining, from cast to assembly,and using a polymer based binding agent (epoxy is just a name brand for a polyester based binding agent) is easier to work with as it has a viscosity close to water (or super thin maple syrup), keeps the mixed material fluid enough that it still runs, doesn't require degassing and trapped air is not a problem if you mix from the bottom up at a slow speed.
As far as using epoxy goes, West Shore Marine sells some stuff that isn't polyester based, resin #205 and harder #209 and a thinning agent (12:1 ratio) they will order for you, is still fluid with aggregate mixed in (not like mashed potatoes), wont need a vibration table and has a work life of about 3hrs (the thinning agent doubles the 90min cure time so natural settling occurs) and 1/2 gallon of resin plus a 1/4 gallon of hardner (0.75gal of mixed resin plus 7.5gal aggregate = 10:1 ratio which is optimal) makes 8.25 gallons of mixed material which can make a fairly decent frame with reasonable size.
If you spend the time making your mold with critical surfaces precision processed you wont need any post processing but of course as the OP has run into, missed inserts and after-thoughts cause problems requiring precision processing to correct.
Attached are some basic 3D drawings of a mill and lathe stripped down to the bare minimum in the event someone would like to try their hand at making a frame and you can scale the design to fit your needs, I only caution you that you will get out of the mold the precision you put into it and not all surfaces require precision so if you think using MDF or countertop material on critical surfaces will give you a good result you should not bother as the end product will only disappoint you.