I built a DPMS style in a .260 Remington and I love that thing but as you say carrying it while hunting is another matter.
To that end my last build was a .25 WSSM on an AR-15 platform, with an Olympic Arms game stalker upper. The ballistics are nearly identical to the .260 but it weighs four pounds less. Both are great long distance rifles.
For a little more close range knock down (for bears and such) I built a .308 with a light weight 18” Kaiser barrel and a carbon fiber hand guard.