The only difficulty in using a x-axis screw is simply remembering to also use a matching nut on that axis for the new thread direction. Also a cheap Taig part.
The reason Taig mills use both right and left hand thread - and the only reason - is that it was originally designed for use as a manual mill. It is simply convention for manual equipment; manual mills do that so the direction of handle rotation is intuitive, and not confusing to the person standing in front of it cranking it. That way on all mills and on all axis, regardless of how it is driven or geared, or the screw is carried or fixed, a clockwise rotation of the handle always moves the axis the same direction relative to the handle. Thats it. Simple. Some machines therefore must use one or more reverse threaded axes to accomplish this. No magic to it.
If it is for
cnc, thread direction is truly irrelevant. Purpose-built
cnc machines almost always use only one direction of thread on all of the axes just for simplicity, unless of course they were a conversion from a manual mill.