What motors do you have attached to them? What do you mean "I set them up"? They should work, I dont know why they wouldnt, you are going to have to troubleshoot. Make sure you have outputs at the printer port first, check the direction pin of one axis, it should change and hold as you switch directions from around 4-5 volts to less than 1 volt. Make sure Mach has the motor outputs enabled and set for port 1, pins 2&3, port 1 pins 4&5, port 1 pins 5 & 6 for the step & direction outputs and verify that you have logic outputs.