The main difference you will have is the torch. You will want something that handles the TorchFire and the OK to Move signals. Then if you want THC you will need something that monitors voltage and adjusts. Check out CandCNC for his THC if you use Mach. You will also want to build a torch holder that has a floating head with a switch so you always know where the material 0 is.
I have my machine setup for 3 tools. Plasma, Engraver and a Spindle so its doable.