I don't know, if this is for production, you might need Featurecam to do something that complex That's a private joke, don't worry if you don't find it funny
Yes, of course you can do this in OneCNC. Set up a style for processing a given hole, in any combination of drilling, profiling, helix down, clean circle operations and save it as a pattern. Call it up again whenever you want to apply it to a new circle pattern. This way, you need not reinvent the wheel over and over.