Yes if it is working correctly. You will need to make sure there are no leaks in your system becasue these pumps have a limited pumping capacity.
I take it you have not done any vacuum degassing like this before? It can get really messy. At the point where the vacuum is strong enough that the mixture starts degassing it can foam up to several times its volume spilling out of the container and getting into vacuum lines. Start off with a very small sample in your bigger container and if you can rig a second container ahead of the pump as a trap it is a good idea. Vacuum pumps don't work very well when they are full of silicone.
Years ago I did quite a bit of silicone degassing with a system using an open top tank something like a paint tank and found the best approach was to put a thick piece of acrylic on the top so I could watch what was happening and open a vent valve if the foaming was getting out of hand. Once the degassing is complete the mix settles back down and the casting results with properly degassed material are far better than you can get without degassing; well worth the hassle.