I had to go look up the model number, that's a monster of a machine... I can't imagine much vibration, but then again, you don't describe the situation very well. What size is the endmill, or indexable cutter? How deep of a cut, into what material, interrupted cut, facing, profiling... what?
There are way too many factors to consider, rigidity of the part, vise, tooling, cutters to be able to give any sort of answer.