I don't have my Mikini yet so I can't speak too much on the CAM side of things but I use RhinoCAM. Rhino is a powerful NURBS modeler and pairs well with VisualMill to create RhinoCAM. The CAD and CAM are associative and integrated so they both run in the same program. They both seem to be very powerful and as with most software also a little quarky. In conversations with Phil (at Mikini) he spoke very highly of VisualMill as opposed to others and said it is probably the best CAM software in its price range on the market. After my own research I eventually went with RhinoCAM Pro. I had used AutoCAD in the past and was satisfied with it and had demo'd OneCNC but in the end I found RhinoCAM way easier to use and more powerful, but that's just me.