Cannot comment on the Spaceball 5000 but we use the Spaceball 3003 model at work.
Software is Catia.
Although I am not a heavy user of Catia I know enough to survive. If not I have to bribe one of the cad designers to help me out
All I can say is it's like having your left arm chopped off when I have to use a cad station without the spaceball fitted. (Not all stations have them fitted)
It really does increase the efficiency of your time. I also find it less tiring on the body.
Not a lot more I can add but they are very good.