The customary way without a Safety relay is to use the simple 3 wire circuit, any other e-stop items are placed in the series string, the relay has contacts that shut off power to the coils of any motive power contactor or relay, the e-stop relay can also have a contact that, say advises the PC an E-stop has taken place and/or disable drives as well as killing the main power to them.
See page 11 for e.g.
http://static.schneider-electric.us/...0140CT9201.pdf
Al.