2/16? that an an eighth of an inch... That's huge... The eye can detect tolerance variations without much trouble down to a 1/100 of an inch, (particularly when inspecting a circle, a trained eye can scrutinize even better.) When you have backlash you end up with oval circles and non square squares, with gouges. your parts won't line up, 3D carvings turn out like blobs and have gouges. Backlash and rigidity are the enemies of CNC... The more you eliminate them the better.
I's not difficult at all to make an antibacklash nut from Delrin or UHMW. So why comprimise. Several of us here have done it with great success.
Regular brass or bronze nuts can be used to a fair degree by using two of them in contention or compression. But there is still some axial play in them that may or may not prove to provide some problems with vibration and or noise.