Half inch thick steel sideplates in that size are not going to flex much at all, the machine will be a lot more rigid than most people's.
One thing I would suggest is to check all the suppliers for the exact lengths that the linear bearing rails (and ballscrews) come in, and adjust the machine dimensions to suit those so you don't have to try to cut the rails or waste inches with rails that are a tiny bit short etc.
And it also looks as though you could extend the length of the machine a bit without increasing the cost much. This again depends on the standard lengths for rails and ballscrews, but it does look like you could make the machine slightly longer (10%? 25%?) with very little added cost (as the gantry remains the same) so it's worth looking into.