I would NOT use nesting to do this for the following reason:
Nesting places parts where IT wants to put them. In other words, you would have to do some real careful figuring to place those screw holes.
It would be much simpler for you to load the panel then TELL vcarve where you want it placed. Load the next panel and place that one, insuring you leave the space for the screw on the sheet.
Another hint here, if you are going to use screws, see if you can find some solid brass wood screws, they cost a bit more, but they are a lot easier on your router bit if you screw up. Sometimes you can even find them in aluminum.
I wasn't really sure what you were asking in your second question?