Hi,
A 2x4 router is a nice size in my view and is about the size mine will be when finished. Not sure how you envision getting a 4x8 sheet into a 2x4 router unless one side is open. If that is the thought I would be concerned about getting a strong enough frame especially if you want to do aluminum as well.
You don't mention what sort of rails you plan to use. Gecko drives are nice but there are other options as well. A quick search through the forum will get you many others.
What sort of spindle are you thinking?
I would concentrate on a solid built 2x4 size with maybe a laminate router as a spindle. Step motors (example Automation Direct) are reasonable in price as are the Gecko drives. Not sure on the rails with your budget. There are several nice designs on this forum using Baltic Birch and MDF. Good luck and keep us posted.