Yes! I swapped out the electronics in mine for the Xylotex 4-axis package, but ANY of the available stepper drivers will run the D&M Sherline.
I changed the power supply and steppers as well, and added a relay control for the Puma spindle controller board.
Recently I burned out that Puma while attempting to add a CNC4PC C6 speed control, and replaced it with a KBIC.
What do ya want for the old stuff?