It is helpful if you use a test indicator to measure how much backlash you have in each axis, in each direction. If it is minor, you can just make sure to keep the ballsrew going in the same direction each time you position the tool to the workpiece. In our situation, our horizontal mill has a tool changer and it has to go down in " Y " axis, ( minus ) and over in " X " axis ( minus ) after each tool change to position to the work piece. If we have critical positions to hold, we just add a jog motion Y +, X +, then Y -, X -, to keep the ballscrew alway positioning from the same direction to take up any backlash.
I know this is not a fixall but it helps if your backlash problem is of a small amount.