MAYCOM: Go to http://www.imserv.com/deskcnc/setup/2.htm, and recheck all of your configurations,per the setup chart. If you find no errors, then go to http://www.imserv.com and click on Trouble shooting the Desk CNC Controller, it is a free download written by Fred Smith of IM Machine. This download has helped me several times.
Some other simple ideas:
1) Check the INI file ( go to my computor, open program files, click on Desk CNC,click on the INI file), take some time you wll see how it is configured..check the INI settings with the ones you have in machine set up.
If it does not match, then change it to the ones you have set up. click save.
2)Are you saving each change and closing Desk CNC each time ?
IF all that fails, post all of your configurations in your thread and I will set up my Mill and see what the problem is, maybe..
It is an excellent program,and I admit that I've made some real blunders in setup, but by studying and a little trial and error, have 2 machines that work like a charm.
Adobe (older than dirt)