Sounds like your drives for axis and spindle have a good chance of working with Camsoft. Need to know more to be sure. Sorry, I don't know what a drill block is, but if the driver just needs step and direction it will also work with Camsoft. Replacing all this equipment is a big part of the expense of re-fitting a machine. Knowing exactly what you need here would go a long way toward making sure your cost estimate and final cost result match.
The next step in getting a good intial estimate of cost would be having a complete list of all the I/O on your machine and what it needs to do. Then we can say what all hardware you need and get a feel of how much custom programming is invloved.
Are you doing the job yourself, or hiring an integrator? This, again will have a great bearing on wheather the inital cost estimate matches final result. The experience level and quality of the integrator you hire will have a huge impact on the whole job. If you're doing it yourself, there's a very steep learning curve for Camsoft.
The software support at Camsoft is GREAT. These folks know their stuff. Keep in mind that Camsoft is an open source type control and can interface all sorts of hardware. I generally go to the manufacture for support in this area.
I'm one of Camsoft's strongest proponents. its simply the best open source control there is, period.