I'm sorry, I thought you meant you were considering whether to build a mill with an aluminum structure vs. steel. I don't have a mini mill, I have a 42" x 20" x 24" vertical
cnc with box ways, 20 hp and 8,000 rpm. The same principles hold true. Minimize the tool length and holder length. Get the cutting edge as close to the spindle bearing as you can. Higher helix is better (45 degrees) even for mild steel. If a four flute face mill chatters, try three edges instead. Variable helix endmills rock. I would try a 1/4" variable helix endmill. No endmill holders. That just adds length away from the bearing. I would collets and choke up on the endmills. I did that when I was running a Bridgeport and had much better results.
Dave