Your setup is complete but you've not specified any tool profiles. How are you going to hold the part down to the table? You'll need to allow for that. What do you want to do with it now? Bore the center hole? Choose 2D, Bore, pick the appropriate tool/bit, and specify the parameters for the cut - geometry, passes, linking, etc., and when you close that dialogue box it should generate a toolpath. Then go to 2D or 3D pocket clearing to cut the recesses around the protrusion and finally choose 2D contour to cut the outer profile of the knob. Does that help?
David