I'm the first to admit that I'm not an absolute expert user of Fusion. However, I have used both Aspire (on a CNC router) and Fusion (programming a Haas mill) quite a bit.
I would personally point you to using Aspire, rather than Fusion 360.
If you are going to be cutting artwork and/or signs on a CNC router, I think most any one of the Vectric softwares will be easier to use, and will be more tailored to what you will be doing.
PM