Is it possible to get Mach 2 or 3 to run a 5 HP columbo ATC spindle.
It looks like the documentation for both states for M6 an XY location
and then mach waits for the cycle start to be pressed after the manual TC.

Wincnc Looks to do this, But is 1500$ bucks by the time you add the ATC feature.

Anyone runinng software the does this or have any input ?

Yes, you can do it, but it'll take some macro programming, and possibly a MODbus board if you need more inputs and/ or outputs. I believe you'll find some guys using ATC's on the Mach2/3 Yahoo group. When you pay the $1500, it's probably basically plug and play, where as with Mach3, you'll have to do it all yourself.