Steve,
I too had a small problem with an Nvidia card. Had to set the color to 16 or 24 bit instead of 32. But I could always open the program. The problem was after doing some work and then rendering. Called Mike at OneCNC and he let me in on the color bit setting thing. After that no problems.
Did you find something different to do?
Are you using a different card?
Please tell us more so we may learn from what you found out.