Not a real good idea, from the viewpoint of how Acme thread specifications are laid out.
In pitchs finer than about 4tpi, the top of the crest, and the root of the thread, have a clearance of .010" (going from memory), which amounts to a .020" gap. So, depending on the backlash of the nuts, your gantry really has nothing to sit on. Add to that the additional wear of the nuts, and you have less bearing than ever.
This built in clearance could add a lot of wobble to your gantry, the further you get from the screw location.
Your idea might sort of work if you had zero backlash ball screws, though. However, even then, it would be best to have two ballscrew nuts per screw, in order to create some kind of a longer, stable base for your gantry.
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